Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Few topics in the MCAS world have generated as much excitement — and as much premature confidence — as the idea of using GLP-1 receptor agonists at sub-therapeutic doses to calm mast cell activation. Social
By Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Most people know endorphins as the "feel-good" chemicals behind a runner's high. But endorphins are far more than a post-workout reward signal—they are potent endogenous opioid peptides
10 Evidence-Based Ways to Naturally Increase Your Endorphins By Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Endorphins are among the most powerful natural molecules your body produces — and yet most people have only a vague sense of what they actually are
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Low dose naltrexone (LDN) has become a cornerstone tool in integrative and functional medicine for autoimmune disease, chronic pain, fibromyalgia, mast cell activation syndrome (MCAS), and a growing list of neuroinflammatory conditions. Most clinicians who
LDN Primer Follow-Up: What to Do When LDN Causes Side Effects A companion piece to the LDN Primer book, exploring how side effects are actually managed in clinical practice. LDN Primer Link: One of the questions I hear most often from readers of my LDN Primer book — and from
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician What this article is — and is not. This is a hypothesis. It proposes a biologically plausible, testable model in which low-dose naltrexone (LDN) might indirectly influence purinergic “cell danger” signaling and, in turn, inflammation-
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician ⚕ Medical Disclaimer This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. The strategies discussed should be implemented only under the guidance of a qualified healthcare provider.
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Published: July 2026 | www.directintegrativecare.com Medical Disclaimer: This article is intended for educational and clinical reference purposes only. It does not establish a physician–client relationship. All therapeutic decisions must be made by the
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician For many women living with endometriosis, hysterectomy is offered — and often accepted — as the "definitive" solution to years of debilitating pelvic pain. Yet a meaningful number of women are dismayed to discover that
Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician July 2026 ⚠ IMPORTANT MEDICAL DISCLAIMER This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Low-dose naltrexone (LDN) is not FDA-approved for mast cell activation
Here are the key LDN teaching points extracted from the education session. LDN teaching points 1. Medication sensitivity can require ultra-low dosing Some MCAS/POTS/EDS patients may not tolerate standard LDN titration. In this case, even 1 microgram caused significant insomnia, suggesting the patient may need nanogram or
Beyond Antioxidants: Through Non-Antioxidant Mechanisms Yoon Hang Kim, MD, MPH Board-Certified in Preventive Medicine | Integrative & Functional Medicine Physician Disclaimer: This article is for educational purposes only and does not constitute medical advice. The information presented summarizes preclinical and early clinical research. Herbs and supplements discussed here should